Differential effects of ketoconazole, itraconazole and voriconazole on the pharmacokinetics of imati...
Differential effects of ketoconazole, itraconazole and voriconazole on the pharmacokinetics of imatinib and its main metabolite GCP74588 in rat
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Author / Creator
Lin, Gaotong , Wang, Chenming , Qiu, Xiangjun , Wang, Zhe , Han, Anyue , Xu, Tao , Kan, Xin and Hu, Guoxin
Publisher
England: Informa Healthcare USA, Inc
Journal title
Language
English
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Publisher
England: Informa Healthcare USA, Inc
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Abstract
The aim of the study was to develop a high performance liquid chromatography method for simultaneous determination of imatinib and CGP74588 in rat serum and study the inhibition effects of ketoconazole, itraconazole and voriconazole on pharmacokinetics of imatinib and CGP74588 in rats. In our study, we found that ketoconazole caused a s...
Alternative Titles
Full title
Differential effects of ketoconazole, itraconazole and voriconazole on the pharmacokinetics of imatinib and its main metabolite GCP74588 in rat
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Record Identifier
TN_cdi_proquest_miscellaneous_1625344499
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1625344499
Other Identifiers
ISSN
0363-9045
E-ISSN
1520-5762
DOI
10.3109/03639045.2013.838582
