Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s di...
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Astrocytic network alterations have been reported in Alzheimer’s disease (AD), but the underlying pathways have remained undefined. Here we measure astrocytic calcium, cerebral blood flow and amyloid-β plaques
in vivo
in a mouse model of AD using multiphoton microscopy. We find that astrocytic hyperactivity, consisting of single-cell transien...
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Full title
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model
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TN_cdi_proquest_miscellaneous_1627070725
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1627070725
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6422
