Conformational Transition Pathway in the Inhibitor Binding Process of Human Monoacylglycerol Lipase
Conformational Transition Pathway in the Inhibitor Binding Process of Human Monoacylglycerol Lipase
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Publisher
New York: Springer US
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Language
English
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New York: Springer US
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Contents
Human monoacylglycerol lipase (MGL) catalyzes the hydrolysis of 2-arachidonoylglycerol to arachidonic and glycerol, which plays a pivotal role in the normal biological processes of brain. Co-crystal structure of the MGL in complex with its inhibitor, compound
1
, shows that the helix α4 undergoes large-scale conformational changes in response...
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Full title
Conformational Transition Pathway in the Inhibitor Binding Process of Human Monoacylglycerol Lipase
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TN_cdi_proquest_miscellaneous_1627077659
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1627077659
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ISSN
1572-3887
E-ISSN
1573-4943,1875-8355
DOI
10.1007/s10930-014-9572-z
