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Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment di...

Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment di...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1639972920

Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment disease-free survival

About this item

Full title

Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment disease-free survival

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2014-12, Vol.5 (1), p.5835-5835, Article 5835

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The arachidonic acid metabolism (AAM) pathway promotes tumour progression. Chemical inhibitors of AAM pathway prolong post-treatment survival of cancer patients. Here we test whether non-synonymous somatic mutations in genes of this pathway, acting as natural inhibitors, increase post-treatment survival. We identify loss-of-function somatic mutatio...

Alternative Titles

Full title

Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment disease-free survival

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1639972920

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1639972920

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms6835

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