T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
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Full title
Author / Creator
Liu, Dan , Xu, Heping , Shih, Changming , Wan, Zurong , Ma, Xiaopeng , Ma, Weiwei , Luo, Dan and Qi, Hai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Interactions between T and B cells in the germinal centre are brief but involve extensive cell-surface contact in an entangled mode; ICOSL promotes T–B entanglement and B-cell acquisition of CD40L, which drives B cells to upregulate ICOSL, thus forming an intercellular feed-forward loop that is required for efficient positive selection and developm...
Alternative Titles
Full title
T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1645779503
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1645779503
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13803
