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The Effect of Polymeric Excipients on the Physical Properties and Performance of Amorphous Dispersio...

The Effect of Polymeric Excipients on the Physical Properties and Performance of Amorphous Dispersio...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1652408886

The Effect of Polymeric Excipients on the Physical Properties and Performance of Amorphous Dispersions: Part I, Free Volume and Glass Transition

About this item

Full title

The Effect of Polymeric Excipients on the Physical Properties and Performance of Amorphous Dispersions: Part I, Free Volume and Glass Transition

Publisher

Boston: Springer US

Journal title

Pharmaceutical research, 2015-02, Vol.32 (2), p.500-515

Language

English

Formats

Publication information

Publisher

Boston: Springer US

More information

Scope and Contents

Contents

Purpose
To investigate the structural effect of polymeric excipients on the behavior of free volume of drug-polymer dispersions in relation to glass transition.
Methods
Two drugs (indomethacin and ketoconazole) were selected to prepare amorphous dispersions with PVP, PVPVA, HPC, and HPMCAS through spray drying. The physical attributes of t...

Alternative Titles

Full title

The Effect of Polymeric Excipients on the Physical Properties and Performance of Amorphous Dispersions: Part I, Free Volume and Glass Transition

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1652408886

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1652408886

Other Identifiers

ISSN

0724-8741

E-ISSN

1573-904X

DOI

10.1007/s11095-014-1478-0

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