Trigger loop folding determines transcription rate of Escherichia coli’s RNA polymerase
Trigger loop folding determines transcription rate of Escherichia coli’s RNA polymerase
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Two components of the RNA polymerase (RNAP) catalytic center, the bridge helix and the trigger loop (TL), have been linked with changes in elongation rate and pausing. Here, single molecule experiments with the WT and two TL-tip mutants of the Escherichia coli enzyme reveal that tip mutations modulate RNAP’s pause-free velocity, identifying TL conf...
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Full title
Trigger loop folding determines transcription rate of Escherichia coli’s RNA polymerase
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Record Identifier
TN_cdi_proquest_miscellaneous_1652409412
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1652409412
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1421067112
