Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
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Author / Creator
Kanno, Atsuo , Tanimura, Natsuko , Ishizaki, Masayuki , Ohko, Kentaro , Motoi, Yuji , Onji, Masahiro , Fukui, Ryutaro , Shimozato, Takaichi , Yamamoto, Kazuhide , Shibata, Takuma , Sano, Shigetoshi , Sugahara-Tobinai, Akiko , Takai, Toshiyuki , Ohto, Umeharu , Shimizu, Toshiyuki , Saitoh, Shin-ichiroh and Miyake, Kensuke
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell surface of immune cells and that TLR7 responses can be inhibited by an anti-TLR7 antibody....
Alternative Titles
Full title
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_1652442274
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1652442274
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7119
