A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia
A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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New York: Nature Publishing Group US
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Scope and Contents
Contents
Pathogenic mutations of the genes encoding isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) occur in people with acute myeloid leukemia or other tumors. A new study identifies a dependence of
IDH
-mutated cells on the anti-apoptosis regulator BCL-2 and indicates a 'synthetic lethal' strategy for the treatment of leukemias.
Alternative Titles
Full title
A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia
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TN_cdi_proquest_miscellaneous_1652461072
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1652461072
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3796
