Defects in T-tubular electrical activity underlie local alterations of calcium release in heart fail...
Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Significance The plasma membrane of cardiac myocytes contains complex invaginations known as transverse tubules (T-tubules). In heart failure, T-tubule loss is a major contributor to Ca ²⁺ transient abnormalities, leading to weaker and slower contraction. Current therapeutic strategies are often based on attempts to accelerate Ca ²⁺ transients. Her...
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Full title
Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure
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TN_cdi_proquest_miscellaneous_1654685054
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1654685054
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1411557111
