PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for exci...
PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Leukocyte common antigen-related receptor protein tyrosine phosphatases—comprising LAR, PTPδ, and PTPσ—are synaptic adhesion molecules that organize synapse development. Here, we identify glypican 4 (GPC-4) as a ligand for PTPσ. GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of PTPσ. PTPσ...
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PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
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TN_cdi_proquest_miscellaneous_1654702766
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1654702766
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1410138112
