Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer ape...
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
About this item
Full title
Author / Creator
Sok, Devin , van Gils, Marit J. , Pauthner, Matthias , Julien, Jean-Philippe , Saye-Francisco, Karen L. , Hsueh, Jessica , Briney, Bryan , Lee, Jeong Hyun , Le, Khoa M. , Lee, Peter S. , Hua, Yuanzi , Seaman, Michael S. , Moore, John P. , Ward, Andrew B. , Wilson, Ian A. , Sanders, Rogier W. and Burton, Dennis R.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Significance Despite the high antigenic diversity of the HIV envelope trimer (Env), broadly neutralizing antibodies (bnAbs) have identified conserved regions that serve as targets for vaccine design. One of these regions is located at the apex of Env and is expressed fully only in the context of the correctly folded trimer. This work describes the...
Alternative Titles
Full title
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_1660399817
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1660399817
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1415789111
