Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
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Publisher
United States: American Association for the Advancement of Science
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Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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Contents
The initial phase in the development of a migraine is still poorly understood. Here, we describe a previously unknown signaling pathway between stressed neurons and trigeminal afferents during cortical spreading depression (CSD), the putative cause of migraine aura and headache. CSD caused neuronal Pannexin1 (Panx1) megachannel opening and caspase-...
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Full title
Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
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TN_cdi_proquest_miscellaneous_1660419119
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1660419119
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1231897
