Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas
Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas
About this item
Full title
Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Arginine deiminase (ADI) is a therapeutic protein for cancer therapy of arginine-auxotrophic tumors. However, ADI’s application as anticancer drug is hampered by its low activity for arginine under physiological conditions mainly due to its high “
K
M
” (S
0.5
) values which are often 1 magnitude higher than the arginine concentratio...
Alternative Titles
Full title
Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1660430805
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1660430805
Other Identifiers
ISSN
0175-7598
E-ISSN
1432-0614
DOI
10.1007/s00253-014-5985-z
