Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
About this item
Full title
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
Author / Creator
Journal title
Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.108 (44 p.18055-18060), p.18055-18060
Language
English
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Scope and Contents
Contents
Interleukin-1α (IL-1α) and -β both bind to the same IL-1 receptor (IL-1R) and are potent proinflammatory cytokines. Production of proinflammatory (pro)-IL-1α and pro-IL-1β is induced by Toll-like receptor (TLR)-mediated NF-κB activation. Additional stimulus involving activation of the inflammasome and caspase-1 is required for proteolytic cleav...
Alternative Titles
Full title
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1663579561
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1663579561
Other Identifiers
ISSN
0027-8424
DOI
10.1073/pnas.1109176108
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