PARma: identification of microRNA target sites in AGO-PAR-CLIP data
PARma: identification of microRNA target sites in AGO-PAR-CLIP data
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
PARma is a complete data analysis software for AGO-PAR-CLIP experiments to identify target sites of microRNAs as well as the microRNA binding to these sites. It integrates specific characteristics of the experiments into a generative model. The model and a novel pattern discovery tool are iteratively applied to data to estimate seed activity probabilities, cluster confidence scores and to assign the most probable microRNA. Based on differential PAR-CLIP analysis and comparison to RIP-Chip data, we show that PARma is more accurate than existing approaches. PARma is available from http://www.bio.ifi.lmu.de/PARma....
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Full title
PARma: identification of microRNA target sites in AGO-PAR-CLIP data
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TN_cdi_proquest_miscellaneous_1663589817
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1663589817
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ISSN
1474-760X
E-ISSN
1474-760X
DOI
10.1186/gb-2013-14-7-r79
