The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node...
The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
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Author / Creator
Astarita, Jillian L , Cremasco, Viviana , Fu, Jianxin , Darnell, Max C , Peck, James R , Nieves-Bonilla, Janice M , Song, Kai , Kondo, Yuji , Woodruff, Matthew C , Gogineni, Alvin , Onder, Lucas , Ludewig, Burkhard , Weimer, Robby M , Carroll, Michael C , Mooney, David J , Xia, Lijun and Turley, Shannon J
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Lymph nodes expand after an inflammatory challenge to accommodate their increased cellularity. Turley and colleagues show that fibroblastic reticular cells regulate this expansion process through the interaction of podoplanin with its receptor CLEC-2 expressed on incoming dendritic cells.
In lymph nodes, fibroblastic reticular cells (FRCs) form...
Alternative Titles
Full title
The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
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Record Identifier
TN_cdi_proquest_miscellaneous_1664195609
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1664195609
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3035
