The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and...
The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), especially for the poor prognostic subgroup of
NOTCH1
-mutated patients. Here, we report that the γ-secretase inhibitor PF-03084014 inhibits the constitutive Notch activation and induces selective apoptosis in CLL cells carrying
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The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells
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TN_cdi_proquest_miscellaneous_1664209153
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1664209153
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2014.143
