Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the...
Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking
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Author / Creator
Sato, A , Nishida, C , Sato-Kusubata, K , Ishihara, M , Tashiro, Y , Gritli, I , Shimazu, H , Munakata, S , Yagita, H , Okumura, K , Tsuda, Y , Okada, Y , Tojo, A , Nakauchi, H , Takahashi, S , Heissig, B and Hattori, K
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The systemic inflammatory response observed during acute graft-versus-host disease (aGVHD) is driven by proinflammatory cytokines, a ‘cytokine storm’. The function of plasmin in regulating the inflammatory response is not fully understood, and its role in the development of aGVHD remains unresolved. Here we show that plasmin is activated during the...
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Full title
Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking
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TN_cdi_proquest_miscellaneous_1664210496
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1664210496
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2014.151
