Rare variants in neuronal excitability genes influence risk for bipolar disorder
Rare variants in neuronal excitability genes influence risk for bipolar disorder
About this item
Full title
Author / Creator
Amenta, Seth A. , Szelinger, Szabolcs , Glusman, Gustavo , Ashworth, Justin , Hou, Liping , Akula, Nirmala , Shekhtman, Tatyana , Badner, Judith A. , Brunkow, Mary E. , Mauldin, Denise E. , Stittrich, Anna-Barbara , Rouleau, Katherine , Detera-Wadleigh, Sevilla D. , Nurnberger, John I. , Edenberg, Howard J. , Gershon, Elliot S. , Schork, Nicholas , Price, Nathan D. , Gelinas, Richard , Hood, Leroy , Craig, David , McMahon, Francis J. , Kelsoe, John R. , Roach, Jared C. , The Bipolar Genome Study and Bipolar Genome Study
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar disorder (BD) to identify contributions of rare variants to genetic risk. We initially focused on 3,087 candidate genes with known synaptic functions or prior evidence from genome-wide association studies. BD pedigrees had an increased burden of rare variant...
Alternative Titles
Full title
Rare variants in neuronal excitability genes influence risk for bipolar disorder
Authors, Artists and Contributors
Author / Creator
Szelinger, Szabolcs
Glusman, Gustavo
Ashworth, Justin
Hou, Liping
Akula, Nirmala
Shekhtman, Tatyana
Badner, Judith A.
Brunkow, Mary E.
Mauldin, Denise E.
Stittrich, Anna-Barbara
Rouleau, Katherine
Detera-Wadleigh, Sevilla D.
Nurnberger, John I.
Edenberg, Howard J.
Gershon, Elliot S.
Schork, Nicholas
Price, Nathan D.
Gelinas, Richard
Hood, Leroy
Craig, David
McMahon, Francis J.
Kelsoe, John R.
Roach, Jared C.
The Bipolar Genome Study
Bipolar Genome Study
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1664779362
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1664779362
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1424958112
