Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
About this item
Full title
Author / Creator
Calon, Alexandre , Lonardo, Enza , Berenguer-Llergo, Antonio , Espinet, Elisa , Hernando-Momblona, Xavier , Iglesias, Mar , Sevillano, Marta , Palomo-Ponce, Sergio , Tauriello, Daniele V F , Byrom, Daniel , Cortina, Carme , Morral, Clara , Barceló, Carles , Tosi, Sebastien , Riera, Antoni , Attolini, Camille Stephan-Otto , Rossell, David , Sancho, Elena and Batlle, Eduard
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Eduard Batlle and colleagues find that poor-outcome subgroups of colorectal cancer are driven by genes expressed in tumor-associated stromal cells. They show that TGF-β expression is a common feature of poor-prognosis subtypes and demonstrate the use of anti–TGF-β molecules in patient-derived tumoroids and xenografts.
Recent molecular classifica...
Alternative Titles
Full title
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Authors, Artists and Contributors
Author / Creator
Lonardo, Enza
Berenguer-Llergo, Antonio
Espinet, Elisa
Hernando-Momblona, Xavier
Iglesias, Mar
Sevillano, Marta
Palomo-Ponce, Sergio
Tauriello, Daniele V F
Byrom, Daniel
Cortina, Carme
Morral, Clara
Barceló, Carles
Tosi, Sebastien
Riera, Antoni
Attolini, Camille Stephan-Otto
Rossell, David
Sancho, Elena
Batlle, Eduard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1667349099
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1667349099
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3225
