Acute DNase1 treatment improves left ventricular remodeling after myocardial infarction by disruptio...
Acute DNase1 treatment improves left ventricular remodeling after myocardial infarction by disruption of free chromatin
About this item
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Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Myocardial infarction (MI) leads to necrosis and uncontrolled release of cellular content. Binucleated and polyploid cardiomyocytes contain high amounts of chromatin, a DNA polymer of histones which are cytotoxic. We hypothesized that chromatin from necrotic cells accumulates in the non-perfused, ischemic infarct region, causing local high concentr...
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Full title
Acute DNase1 treatment improves left ventricular remodeling after myocardial infarction by disruption of free chromatin
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1668247381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1668247381
Other Identifiers
ISSN
0300-8428
E-ISSN
1435-1803
DOI
10.1007/s00395-015-0472-y
