Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against...
Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis
About this item
Full title
Author / Creator
van Heemst, Jurgen , Jansen, Diahann T. S. L. , Polydorides, Savvas , Moustakas, Antonis K. , Bax, Marieke , Feitsma, Anouk L. , Bontrop-Elferink, Diënne G. , Baarse, Martine , van der Woude, Diane , Wolbink, Gert-Jan , Rispens, Theo , Koning, Frits , de Vries, René R. P. , Papadopoulos, George K. , Archontis, Georgios , Huizinga, Tom W. and Toes, René E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The HLA locus is the strongest risk factor for anti-citrullinated protein antibody (ACPA)
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rheumatoid arthritis (RA). Despite considerable efforts in the last 35 years, this association is poorly understood. Here we identify (citrullinated) vinculin, present in the joints of ACPA
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RA patients, as an autoantigen targeted by ACPA and CD...
Alternative Titles
Full title
Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis
Authors, Artists and Contributors
Author / Creator
Jansen, Diahann T. S. L.
Polydorides, Savvas
Moustakas, Antonis K.
Bax, Marieke
Feitsma, Anouk L.
Bontrop-Elferink, Diënne G.
Baarse, Martine
van der Woude, Diane
Wolbink, Gert-Jan
Rispens, Theo
Koning, Frits
de Vries, René R. P.
Papadopoulos, George K.
Archontis, Georgios
Huizinga, Tom W.
Toes, René E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1680186411
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1680186411
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7681
