Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Synd...
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
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Author / Creator
Bentley-Lewis, Rhonda, MD , Aguilar, David, MD , Riddle, Matthew C., MD , Claggett, Brian, PhD , Diaz, Rafael, MD , Dickstein, Kenneth, MD, PhD , Gerstein, Hertzel C., MD , Johnston, Peter, MD , Køber, Lars V., MD , Lawson, Francesca, MD , Lewis, Eldrin F., MD , Maggioni, Aldo P., MD , McMurray, John J.V., MD , Ping, Lin, MD , Probstfield, Jeffrey L., MD , Solomon, Scott D., MD , Tardif, Jean-Claude, MD , Wu, Yujun, PhD , Pfeffer, Marc A., MD, PhD and ELIXA Investigators
Publisher
United States: Elsevier Inc
Journal title
Language
English
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Publisher
United States: Elsevier Inc
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Scope and Contents
Contents
Background Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated. Methods ELIXA ( www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV...
Alternative Titles
Full title
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
Authors, Artists and Contributors
Author / Creator
Aguilar, David, MD
Riddle, Matthew C., MD
Claggett, Brian, PhD
Diaz, Rafael, MD
Dickstein, Kenneth, MD, PhD
Gerstein, Hertzel C., MD
Johnston, Peter, MD
Køber, Lars V., MD
Lawson, Francesca, MD
Lewis, Eldrin F., MD
Maggioni, Aldo P., MD
McMurray, John J.V., MD
Ping, Lin, MD
Probstfield, Jeffrey L., MD
Solomon, Scott D., MD
Tardif, Jean-Claude, MD
Wu, Yujun, PhD
Pfeffer, Marc A., MD, PhD
ELIXA Investigators
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1680958633
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1680958633
Other Identifiers
ISSN
0002-8703
E-ISSN
1097-6744
DOI
10.1016/j.ahj.2015.02.002
