Downregulation of HO-1 promoted apoptosis induced by decitabine via increasing p15 super(INK4B) prom...
Downregulation of HO-1 promoted apoptosis induced by decitabine via increasing p15 super(INK4B) promoter demethylation in myelodysplastic syndrome
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English
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Decitabine, which reverses hypermethylation of the p15 super(INK4B) gene in vitro, has been used to relieve cytopenias and blast excess in over 50% of patients with high-risk myelodysplastic syndrome (MDS). In this study, heme oxygenase-1 (HO-1) was overexpressed in MDS cell line SKM-1, which was closely related to resistance to decitabine-induced...
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Full title
Downregulation of HO-1 promoted apoptosis induced by decitabine via increasing p15 super(INK4B) promoter demethylation in myelodysplastic syndrome
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TN_cdi_proquest_miscellaneous_1683354200
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1683354200
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ISSN
0969-7128
DOI
10.1038/gt.2015.1
