Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Ovarian tumors with common mutations in the epigenetic regulator ARID1A are shown to be sensitive to inhibition of EZH2, another epigenetic regulator, showing a synthetic lethality that could potentially be exploited therapeutically
The gene encoding ARID1A, a chromatin remodeler, shows one of the highest mutation rates across many cancer types....
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Full title
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
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TN_cdi_proquest_miscellaneous_1694968198
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1694968198
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3799
