Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte function...
Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions
About this item
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Author / Creator
Schachtrup, Christian , Ryu, Jae Kyu , Mammadzada, Könül , Khan, Abdullah S , Carlton, Peter M , Perez, Alex , Christian, Frank , Le Moan, Natacha , Vagena, Eirini , Baeza-Raja, Bernat , Rafalski, Victoria , Chan, Justin P , Nitschke, Roland , Houslay, Miles D , Ellisman, Mark H , Wyss-Coray, Tony , Palop, Jorge J and Akassoglou, Katerina
Publisher
United States
Journal title
Language
English
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Publication information
Publisher
United States
Subjects
More information
Scope and Contents
Contents
Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75(NTR) interacts with nucleopori...
Alternative Titles
Full title
Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions
Authors, Artists and Contributors
Author / Creator
Ryu, Jae Kyu
Mammadzada, Könül
Khan, Abdullah S
Carlton, Peter M
Perez, Alex
Christian, Frank
Le Moan, Natacha
Vagena, Eirini
Baeza-Raja, Bernat
Rafalski, Victoria
Chan, Justin P
Nitschke, Roland
Houslay, Miles D
Ellisman, Mark H
Wyss-Coray, Tony
Palop, Jorge J
Akassoglou, Katerina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1700106040
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1700106040
Other Identifiers
E-ISSN
1546-1726
DOI
10.1038/nn.4054
