Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control usi...
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Significance PINK1 protein kinase and PARKIN UB ligase are mutated in inherited forms of Parkinson’s disease and several cancers. Thus, it is of great significance to understand normal functions that could be disrupted in disease. A role for PARKIN and PINK1 is in mediating autophagy of damaged mitochondria (mitophagy) through polyubiquitylation of...
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Full title
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
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TN_cdi_proquest_miscellaneous_1701483621
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1701483621
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1506593112
