p53 protein aggregation promotes platinum resistance in ovarian cancer
p53 protein aggregation promotes platinum resistance in ovarian cancer
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Author / Creator
Yang-Hartwich, Y , Soteras, M G , Lin, Z P , Holmberg, J , Sumi, N , Craveiro, V , Liang, M , Romanoff, E , Bingham, J , Garofalo, F , Alvero, A and Mor, G
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
High-grade serous ovarian carcinoma (HGSOC), the most lethal gynecological cancer, often leads to chemoresistant diseases. The p53 protein is a key transcriptional factor regulating cellular homeostasis. A majority of HGSOCs have inactive p53 because of genetic mutations. However, genetic mutation is not the only cause of p53 inactivation. The aggr...
Alternative Titles
Full title
p53 protein aggregation promotes platinum resistance in ovarian cancer
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Record Identifier
TN_cdi_proquest_miscellaneous_1701499537
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1701499537
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2014.296
