Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
A fusion protein containing P450 and aldo-keto reductase domains is shown to catalyze reticuline isomerization, the critical branch point between the noscapine and morphine biosynthetic pathways. This discovery completes the enzymatic route to morphine and related compounds.
The gateway to morphine biosynthesis in opium poppy (
Papaver somnif...
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Full title
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy
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TN_cdi_proquest_miscellaneous_1705734410
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1705734410
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1879
