Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
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United States: National Acad Sciences
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Language
English
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United States: National Acad Sciences
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Contents
Mutations in genes encoding proteins that function in splicing of mRNA precursors occur frequently in myelodysplastic syndromes (MDS) and certain leukemias. However, the mechanism by which the mutated splicing factors function has begun to be elucidated only recently. Here we use genome-editing techniques to introduce a common MDS mutation in the g...
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Full title
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
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TN_cdi_proquest_miscellaneous_1707556380
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1707556380
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1514105112
