Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tu...
Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis
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Publisher
United States: National Acad Sciences
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Language
English
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Publisher
United States: National Acad Sciences
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Contents
Multidrug resistance, strong side effects, and compliance problems in TB chemotherapy mandate new ways to kill Mycobacterium tuberculosis (Mtb). Here we show that deletion of the gene encoding homoserine transacetylase (metA) inactivates methionine and S-adenosylmethionine (SAM) biosynthesis in Mtb and renders this pathogen exquisitely sensitive to...
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Full title
Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis
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Record Identifier
TN_cdi_proquest_miscellaneous_1722172200
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1722172200
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1513033112
