The Mouse Clock Mutation Reduces Circadian Pacemaker Amplitude and Enhances Efficacy of Resetting St...
The Mouse Clock Mutation Reduces Circadian Pacemaker Amplitude and Enhances Efficacy of Resetting Stimuli and Phase-Response Curve Amplitude
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The mouse Clock gene encodes a basic helix-loop-helix-PAS transcription factor, CLOCK, that acts in concert with BMAL1 to form the positive elements of the circadian clock mechanism in mammals. The original Clock mutant allele is a dominant negative (antimorphic) mutation that deletes exon 19 and causes an internal deletion of 51 aa in the C-termin...
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Full title
The Mouse Clock Mutation Reduces Circadian Pacemaker Amplitude and Enhances Efficacy of Resetting Stimuli and Phase-Response Curve Amplitude
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TN_cdi_proquest_miscellaneous_17267380
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17267380
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0603601103
