RANKL inhibition combined with tamoxifen treatment increases anti-tumor efficacy and prevents tumor-...
RANKL inhibition combined with tamoxifen treatment increases anti-tumor efficacy and prevents tumor-induced bone destruction in an estrogen receptor-positive breast cancer bone metastasis model
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Publisher
Boston: Springer US
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Language
English
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Publisher
Boston: Springer US
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Contents
Tumor cells in bone can induce the activation of osteoclasts, which mediate bone resorption and release of growth factors and calcium from the bone matrix, resulting in a cycle of tumor growth and bone breakdown. Targeting the bone microenvironment by the inhibition of RANKL, an essential mediator of osteoclast function, not only prevents tumor-ind...
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Full title
RANKL inhibition combined with tamoxifen treatment increases anti-tumor efficacy and prevents tumor-induced bone destruction in an estrogen receptor-positive breast cancer bone metastasis model
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TN_cdi_proquest_miscellaneous_1732831774
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1732831774
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ISSN
0167-6806
E-ISSN
1573-7217
DOI
10.1007/s10549-012-2222-2
