JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old...
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
About this item
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We found a higher burden of senescen...
Alternative Titles
Full title
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
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Record Identifier
TN_cdi_proquest_miscellaneous_1735335492
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1735335492
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1515386112
