Role of DNA Mismatch Repair and p53 in Signaling Induction of Apoptosis by Alkylating Agents
Role of DNA Mismatch Repair and p53 in Signaling Induction of Apoptosis by Alkylating Agents
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United States: National Academy of Sciences of the United States of America
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English
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United States: National Academy of Sciences of the United States of America
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All cells are unavoidably exposed to chemicals that can alkylate DNA to form genotoxic damage. Among the various DNA lesions formed, O6-alkylguanine lesions can be highly cytotoxic, and we recently demonstrated that O6-methylguanine (O6MeG) and O6-chloroethylguanine (O6CEG) specifically initiate apoptosis in hamster cells. Here we show, in both ham...
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Full title
Role of DNA Mismatch Repair and p53 in Signaling Induction of Apoptosis by Alkylating Agents
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TN_cdi_proquest_miscellaneous_17407190
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17407190
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.19.10764
