Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
IgG4 antibodies can exchange Fab arms and show different affinities for Fc receptors than do other IgG subclasses. The structure of full-length pembrolizumab, a human IgG4 approved to treat advanced melanoma, provides a framework to understand IgG4's properties.
Immunoglobulin G4 antibodies exhibit unusual properties with important biological co...
Alternative Titles
Full title
Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1747329207
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1747329207
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3129
