Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissibl...
Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy
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Publisher
Oxford: Elsevier Ltd
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Language
English
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Publisher
Oxford: Elsevier Ltd
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Contents
To test whether prion protein (PrP) specific secretory immunoglobulin A (sIgA) can be induced and protect against oral transmission of spongiform encephalopathy (SE) we immunized Balb/c mice either intragastrically or intranasally (i.n.) with a recombinant PrP-fragment (PrP90-231) and cholera toxin (CT) adjuvant. Since PrP90-231 was rapidly digeste...
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Full title
Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy
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TN_cdi_proquest_miscellaneous_17483082
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17483082
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ISSN
0264-410X
E-ISSN
1873-2518
DOI
10.1016/j.vaccine.2005.12.051
