Gain-of-Function Amino Acid Substitutions Drive Positive Selection of FGFR2 Mutations in Human Sperm...
Gain-of-Function Amino Acid Substitutions Drive Positive Selection of FGFR2 Mutations in Human Spermatogonia
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Despite the importance of mutation in genetics, there are virtually no experimental data on the occurrence of specific nucleotide substitutions in human gametes. C>G transversions at position 755 of FGF receptor 2 (FGFR2) cause Apert syndrome; this mutation, encoding the gain-of-function substitution Ser252Trp, occurs with a birth rate elevated 200...
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Full title
Gain-of-Function Amino Acid Substitutions Drive Positive Selection of FGFR2 Mutations in Human Spermatogonia
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TN_cdi_proquest_miscellaneous_17491787
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17491787
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0500267102
