Foxp3 Interacts with Nuclear Factor of Activated T Cells and NF-κB to Repress Cytokine Gene Expressi...
Foxp3 Interacts with Nuclear Factor of Activated T Cells and NF-κB to Repress Cytokine Gene Expression and Effector Functions of T Helper Cells
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Scurfy mice, which are deficient in a functional Foxp3, exhibit a severe lymphoproliferative disorder and display generalized overproduction of cytokines. Here, we show that, among the Foxp transcriptional factor family, which includes Foxp1, Foxp2, and Foxp3, only Foxp3 has the ability to inhibit IL-2, IL-4, and IFN-γ production by primary T helpe...
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Full title
Foxp3 Interacts with Nuclear Factor of Activated T Cells and NF-κB to Repress Cytokine Gene Expression and Effector Functions of T Helper Cells
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TN_cdi_proquest_miscellaneous_17492544
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17492544
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0501675102
