Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis?
Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis?
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United States: The University of Chicago Press
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Language
English
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Publisher
United States: The University of Chicago Press
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Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in...
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Full title
Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis?
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TN_cdi_proquest_miscellaneous_17508985
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17508985
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ISSN
1058-4838
E-ISSN
1537-6591
DOI
10.1086/430441
