The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole...
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study
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Author / Creator
Finn, Richard S, MD , Crown, John P, Prof , Lang, Istvan, MD , Boer, Katalin, MD , Bondarenko, Igor M, Prof , Kulyk, Sergey O, MD , Ettl, Johannes, MD , Patel, Ravindranath, MD , Pinter, Tamas, MD , Schmidt, Marcus, MD , Shparyk, Yaroslav, MD , Thummala, Anu R, MD , Voytko, Nataliya L, MD , Fowst, Camilla, MD , Huang, Xin, PhD , Kim, Sindy T, BS , Randolph, Sophia, MD and Slamon, Dennis J, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
Summary Background Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 with preclinical evidence of growth-inhibitory activity in oestrogen receptor-positive breast cancer cells and synergy with anti-oestrogens. We aimed to assess the safety and efficacy of palbociclib in combination with letrozo...
Alternative Titles
Full title
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study
Authors, Artists and Contributors
Author / Creator
Crown, John P, Prof
Lang, Istvan, MD
Boer, Katalin, MD
Bondarenko, Igor M, Prof
Kulyk, Sergey O, MD
Ettl, Johannes, MD
Patel, Ravindranath, MD
Pinter, Tamas, MD
Schmidt, Marcus, MD
Shparyk, Yaroslav, MD
Thummala, Anu R, MD
Voytko, Nataliya L, MD
Fowst, Camilla, MD
Huang, Xin, PhD
Kim, Sindy T, BS
Randolph, Sophia, MD
Slamon, Dennis J, Prof
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1751215637
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1751215637
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(14)71159-3
