Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-esc...
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
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Author / Creator
Falchook, Gerald S, Dr , Lewis, Karl D, MD , Infante, Jeffrey R, MD , Gordon, Michael S, MD , Vogelzang, Nicholas J, MD , DeMarini, Douglas J, PhD , Sun, Peng, PhD , Moy, Christopher, MS , Szabo, Stephen A, BA , Roadcap, Lori T, MS , Peddareddigari, Vijay GR, MD , Lebowitz, Peter F, MD , Le, Ngocdiep T, MD , Burris, Howard A, MD , Messersmith, Wells A, MD , O'Dwyer, Peter J, Prof , Kim, Kevin B, MD , Flaherty, Keith, MD , Bendell, Johanna C, MD , Gonzalez, Rene, Prof , Kurzrock, Razelle, Prof and Fecher, Leslie A, MD
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
Summary Background MEK is a member of the MAPK signalling cascade that is commonly activated in melanoma. Direct inhibition of MEK blocks cell proliferation and induces apoptosis. We aimed to analyse safety, efficacy, and genotyping data for the oral, small-molecule MEK inhibitor trametinib in patients with melanoma. Methods We undertook a multicen...
Alternative Titles
Full title
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
Authors, Artists and Contributors
Author / Creator
Lewis, Karl D, MD
Infante, Jeffrey R, MD
Gordon, Michael S, MD
Vogelzang, Nicholas J, MD
DeMarini, Douglas J, PhD
Sun, Peng, PhD
Moy, Christopher, MS
Szabo, Stephen A, BA
Roadcap, Lori T, MS
Peddareddigari, Vijay GR, MD
Lebowitz, Peter F, MD
Le, Ngocdiep T, MD
Burris, Howard A, MD
Messersmith, Wells A, MD
O'Dwyer, Peter J, Prof
Kim, Kevin B, MD
Flaherty, Keith, MD
Bendell, Johanna C, MD
Gonzalez, Rene, Prof
Kurzrock, Razelle, Prof
Fecher, Leslie A, MD
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1751230385
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1751230385
Other Identifiers
ISSN
1470-2045,1474-5488
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(12)70269-3
