Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Obesity is shown in a mouse model of liver cancer to strongly enhance tumorigenesis; a high fat diet alters the composition of intestinal bacteria, leading to more production of the metabolite DCA which, probably together with other factors, induces senescence and the secretion of various senescence-associated cytokines in hepatic stellate cells, t...
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Full title
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
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TN_cdi_proquest_miscellaneous_1758241448
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1758241448
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12347
