Tumor-Promoting Phorbol Esters and Activated Ras Inactivate the Tuberous Sclerosis Tumor Suppressor...
Tumor-Promoting Phorbol Esters and Activated Ras Inactivate the Tuberous Sclerosis Tumor Suppressor Complex via p90 Ribosomal S6 Kinase
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or TSC2, which encode hamartin and tuberin, respectively. Tuberin and hamartin form a complex that inhibits signaling by the mammalian target of rapamycin (mTOR), a critical nutrient sensor and regulator of cell growth and pro...
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Full title
Tumor-Promoting Phorbol Esters and Activated Ras Inactivate the Tuberous Sclerosis Tumor Suppressor Complex via p90 Ribosomal S6 Kinase
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TN_cdi_proquest_miscellaneous_17603791
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17603791
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0405659101
