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Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C su...

Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C su...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17604531

Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C sub(5)-C sub(16) degradation fragment of reidispongiolide A

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Full title

Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C sub(5)-C sub(16) degradation fragment of reidispongiolide A

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.11986-11991

Language

English

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Subjects

Subjects and topics

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Scope and Contents

Contents

Reidispongiolide A is a representative member of the sphinxolide/reidispongiolide group of cytotoxic 26-membered macrolides of marine origin. By interacting with actin in the cell cytoskeleton, the reidispongiolides and sphinxolides are potent microfilament destabilizing agents that represent a promising mechanism of action for developing novel ant...

Alternative Titles

Full title

Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C sub(5)-C sub(16) degradation fragment of reidispongiolide A

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Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_17604531

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17604531

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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