Reduced expression of voltage-gated Kv11.1 (hERG) K+ channels in aganglionic colon in Hirschsprung’s...
Reduced expression of voltage-gated Kv11.1 (hERG) K+ channels in aganglionic colon in Hirschsprung’s disease
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Berlin/Heidelberg: Springer Berlin Heidelberg
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English
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Berlin/Heidelberg: Springer Berlin Heidelberg
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Purpose
The pathophysiology of Hirschsprung’s disease (HSCR) is not entirely understood. There is no clear explanation for the occurrence of the spastic or tonically contracted aganglionic segment of bowel. Kv11.1 (hERG) channels play a critical role in the regulation of the resting membrane potential as well as affecting either the force or fre...
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Full title
Reduced expression of voltage-gated Kv11.1 (hERG) K+ channels in aganglionic colon in Hirschsprung’s disease
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TN_cdi_proquest_miscellaneous_1760854105
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1760854105
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ISSN
0179-0358
E-ISSN
1437-9813
DOI
10.1007/s00383-015-3807-8