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Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhib...

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhib...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1762362535

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine: e0125898

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Full title

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine: e0125898

Journal title

PloS one, 2015-05, Vol.10 (5)

Language

English

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Scope and Contents

Contents

Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene are responsible for over 80% of DS cases. While DS is largely resistant to treatment with existing anti-epileptic drugs, promising results have been obtained in clinical trials with human pati...

Alternative Titles

Full title

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine: e0125898

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Record Identifier

TN_cdi_proquest_miscellaneous_1762362535

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1762362535

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E-ISSN

1932-6203

DOI

10.1371/journal.pone.0125898

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