HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Key Points
Erythropoietin production is controlled by hypoxia inducible factor (HIF); the prolyl hydroxylase domain-containing (PHD) enzymes regulate HIF and act as molecular oxygen sensors
Small-molecule inhibitors of the PHD enzymes increase erythropoietin production and are in clinical development for the treatment of renal anaemia
Adva...
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Full title
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
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TN_cdi_proquest_miscellaneous_1767068842
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1767068842
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ISSN
1759-5061
E-ISSN
1759-507X
DOI
10.1038/nrneph.2015.193
