Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Amyloid-β (Aβ) is generated by BACE-1-mediated cleavage of amyloid precursor protein (APP), and its deposition is a pathological hallmark of Alzheimer's disease. The authors find that APP and BACE-1 interact in biosynthetic and endocytic compartments in neurons. In axons, APP and BACE-1 interact during cotransport. The Alzheimer's disease–protectiv...
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Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
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TN_cdi_proquest_miscellaneous_1768582816
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1768582816
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4188
